Promoting the Activity of a Receptor Tyrosine Phosphatase with a Novel pH‐responsive Transmembrane Agonist Inhibits Cancer‐Associated Phenotypes. Rizzo, S.; Sikorski, E.; Park, S.; Im, W.; Vasquez‐Montes, V.; Ladokhin, A. S.; Thévenin, D. Protein Science,
2023, 32(9):e4742. doi:10.1002/pro.4742.
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Disrupting PTPRJ transmembrane-mediated oligomerization counteracts oncogenic receptor tyrosine kinase FLT3 ITD. Schwarz, M.; Rizzo, S.; Espinoza Paz, W.; Kresinsky, A.; Thévenin, D.; Müller, J.P. Front. Oncol.,
2022, 12:1017947. doi:10.3389/fonc.2022.1017947.
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Ca2+ and Mg2+ Influence the Thermodynamics of Peptide-Membrane Interactions. Vasquez-Montes, V.; Goldberg, A.F. X.; Thévenin, D.; Ladokhin, A.S. J. Mol. Bio,
2022, 434(21):167826. doi:110.1016/j.jmb.2022.167826.
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Ca2+ -dependent interactions between lipids and the tumor-targeting peptide pHLIP. Vasquez-Montes V*, Tyagi V*, Sikorski E*, Kyrychenko A, Freites JA, Thévenin D, Tobias DJ, Ladokhin AS. Protein Science,
2022, 31(9):e4385. doi:10.1002/pro.4385. (*equal contribution)
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Selective Display of a Chemoattractant Agonist on Cancer Cells Activates the Formyl Peptide Receptor 1 on Immune Cells. Sikorski E, Wehr J, Ferraro NJ, Rizzo S, Pires MM, Thévenin, D. ChemBioChem,
2022, 23(8):e202100521. doi:10.1002/cbic.202100521.
PubMed
pH-Dependent Grafting of
Cancer Cells with Antigenic Epitopes Promotes Selective
Antibody-Mediated Cytotoxicity. Wehr J, Sikorski EL,
Bloch E, Feigman MS, Ferraro NJ, Baybutt TR, Snook AE, Pires MM,
Thévenin D. J Med Chem.,
2020, 63 (7), 3713–3722. doi: 10.1021/acs.jmedchem.0c00016.
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Divalent Cations and Lipid
Composition Modulate Membrane Insertion and Cancer-Targeting
Action of pHLIP. Vasquez-Montes V, Gerhart J, Damien
Thévenin, Ladokhin AS. J. Mol. Bio,
2019; doi: 10.1016/j.jmb.2019.10.016.
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Disrupting the transmembrane
domain-mediated oligomerization of protein tyrosine
phosphatase receptor J inhibits EGFR-driven cancer cell
phenotypes. Elizabeth Bloch*, Eden L. Sikorski*,
David Pontoriero, Bryan Berger, Matthew J. Lazzara, Damien
Thévenin. J. Biol. Chem,
2019; doi: 10.1074/jbc.RA119.010229.
(*equal contribution) PubMed
Inhibiting Epidermal Growth
Factor Receptor Dimerization and Signaling Through Targeted
Delivery of a Juxtamembrane Domain Peptide Mimic.
Gerhart J, Thévenin AF , Bloch E, King KE, Thévenin D. ACS
Chem Biol., 2018,
21;13(9):2623–32. PubMed
Comparison of lipid-dependent bilayer insertion of
pHLIP and its P20G variant. Vasquez-Montes V, Gerhart
J, King KE, Thévenin D, Ladokhin AS. BBA Biomembranes, 2017,
1860(2):534–43. PubMed
Therapeutic Efficacy of a Family of pHLIP-MMAF
Conjugates in Cancer Cells and Mouse Models. Burns
KE, Hensley HH, Robinson MK, Thévenin D. Molecular
Pharmaceutics, 2017, Feb
6;14(2):415-422. PubMed
pH-Selective Cytotoxicity of pHLIP-Antimicrobial
Peptide Conjugates. Burns KE, McCleerey TP (UG),
Thévenin D. Scientific Reports, 2016,
2016;6:28465. PubMed
Down-regulation of PAR1 activity with a pHLIP-based
allosteric antagonist induces cancer cell death. Burns
KE, Thévenin D. Biochemical Journal, 2015,
472(3), 287–95. PubMed
Taming Amphotericin B. Janout V, Schell WA,
Thévenin D, Yu Y, Perfect JR, Regen SL. Bioconjug Chem,
2015, 26(10), 2021–4.
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Inhibition of Cancer Cell Proliferation and Breast
Tumor Targeting of pHLIP-Monomethyl Auristatin E Conjugates.
Burns K, Robinson M, Thévenin D. Molecular Pharmaceutics,
2015, 12(4), 1250–8. PubMed
Peptide targeting and imaging of damaged lung tissue
in influenza-infected mice. Li N, Yin L, Thévenin D,
Yamada Y, Limmon G, Chen J, et al. Future Microbiol, 2013,
8, 257–69. PubMed
Identifying and Measuring Transmembrane Helix-Helix
Interactions by FRET. Thévenin D*, Lazarova T. Methods
Mol Biol, 2012, 914, 87–106. PubMed
Thrombopoietin receptor activation: transmembrane
helix dimerization, rotation, and allosteric modulation. Matthews
EE*, Thévenin D*, Rogers JM, Gotow L, Lira PD, Reiter LA,
William H Brissette, Donald M Engelman. FASEB Journal,
2011, 25(7), 2234–44. (*equal contribution). PubMed
pHLIP-mediated translocation of membrane-impermeable
molecules into cells. Thévenin D, An M, Engelman DM.
Chemistry & Biology, 2009, 16(7),
754–62. PubMed
Stable interactions between the transmembrane domains
of the adenosine A2A receptor. Thévenin D*, Lazarova
T. (2008). Protein Science, 2008,
17(7), 1188–99. PubMed
Identifying interactions between transmembrane helices
from the adenosine A2A receptor. Thévenin D, Roberts
MF, Lazarova T, Robinson CR. Biochemistry, 2005,
44(49), 16239–45.
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Oligomerization of the fifth transmembrane domain from
the adenosine A2A receptor. Thévenin D, Lazarova T,
Roberts MF, Robinson CR. Protein Science, 2005,
14(8), 2177–86. PubMed