The Thévenin Lab

Membrane Protein Biophysics: Transduction and Modulation of Receptor Signaling

Membrane Biophysics & Drug Delivery


  • Burns K, McCleerey TP, Thévenin D. (2016) pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates. Scientific Reports, 6, 28465; doi: 10.1038/srep28465 - PubMed - PDF
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  • Burns K, Thévenin D. (2015) Down-regulation of PAR1 Activity with a pHLIP-based Allosteric Antagonist Induces Cancer Cell Death. Biochemical Journal, 472(3), 287-95 - PubMed - PDF
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  • Janout V, Schell WA, Thévenin D, Yu Y, Perfect JR and Regen SL (2015) Taming Amphotericin B. Bioconjugate Chemistry 26(10):2021-4 PubMed - PDF

  • Burns K, Robinson M, Thévenin D. (2015) Inhibition of cancer cell proliferation and breast tumor targeting of pHLIP-monomethyl auristatin E conjugates. Molecular Pharmaceutics 12(4), 1250-1258 PubMed - PDF
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  • Li N, Yin L, Thévenin D, Yamada Y, Limmon G, Chen J, Chow VTK, Engelman DM and Engelward B. (2013) Peptide targeting and imaging of damaged lung tissue un influenza-infected mouse. Future Microbiology 8, 257-269. PubMed - PDF
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  • Thévenin D and Lazarova T. (2012) Identifying and measuring transmembrane helix-helix interactions by FRET. Methods in Molecular Biology 914:87-106. Book Title: Membrane Protein Structure and Dynamics: Methods and Protocols. PDF
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  • Matthews EE, Thévenin D*, Rogers JM, Gotow L, Lira PD, Reiter LA, Brissette WH, and Engelman, DM. (2011) Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation. The FASEB Journal 25, 2234–2244. *Co-first author. PDF
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  • Thévenin D, An M, and Engelman DM. (2009) pHLIP-mediated translocation of membrane-impermeable molecules in to cells. Chemistry & Biology 16(7), 754-762. PDF
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  • Thévenin D, Lazarova T (2008) Stable interactions between transmembrane domains of the adenosine A2A receptor. Protein Science 17, 1188-1199. PDF

  • Thévenin D, Lazarova T, Roberts M and Robinson CR (2005) Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor. Protein Science 14(8) 2177-2186. PDF

  • Thévenin D, Lazarova T, Roberts M and Robinson CR (2005) Identifying interactions between transmembrane helices from the adenosine A2A receptor. Biochemistry 44, 16239-16245. PDF