The Thévenin Lab

Membrane Protein Biophysics: Transduction and Modulation of Receptor Signaling

Membrane Biophysics & Drug Delivery

Jan 2017
Jun 2016
Dec 2015
Oct 2015
Sep 2015
Aug 2015
Mar 2015
Jul 2014
Jun 2014
Mar 2014
Nov 2013
Sep 2013
Jun 2013
May 2013
Jan 2013
May 2012
Jan 2012
Oct 2011
Sep 2011
Aug 2011

Our latest work just got published

Our work on the selective in vivo delivery and efficacy of pHLIP-MMAF conjugates just got published in Molecular Pharmaceutics: http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.6b00847

Congratulations to Dr. Kelly Burns!

Congratulations to Dr. Burns, who successfully defended her Ph.D. Thesis. She is the first PhD student to graduate from the Thévenin Lab. We are all very proud of her. She will continue her research endeavor at the US Naval Research Laboratory (Center for Biomolecular Science & Engineering) in Washington, D.C.

Work on deliverying antimicrobial peptides to cancer cells published in Scientific Reports

Check out Kelly’s new article at Scientific Report:Burns K, McCleerey TP, Thévenin D. (2016) pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates. Scientific Reports, 6, 28465; doi: 10.1038/srep28465 - link - PDF

NIH-NCI Grant on Receptor Protein-Tyrosine Phosphatases

Our lab was awarded an NIH-NCI R21 grant to determine how a receptor protein tyrosine phosphatase physically interacts with itself and with the epidermal growth factor receptor, and how these interactions affect EGFR tyrosine phosphorylation.

pHLIP research covered by Lehigh News

A Cancer Research Team Hits Its Target:
http://www1.lehigh.edu/news/cancer-research-team-hits-its-target

Kelly has published her 2nd article!

Kelly’s second papers has just been accepted for publication in the Biochemical Journal. Congratulations to Kelly!
Down-Regulation of PAR1 Activity with a pHLIP-based Allosteric Antagonist Induces Cancer Cell Death

Congratulations to Janessa

Janessa has successfully defended her Ph.D. Thesis Proposal, and she is now a Ph.D. candidate!

First Article From the Lab!

The first manuscript form our lab has just been accepted in Molecular Pharmaceutics!! Congratulations to Kelly!
Inhibition of Cancer Cell Proliferation and Breast Tumor Targeting of pHLIP-monomethyl Auristatin E Conjugates

Congratulations to Betty

Betty has successfully defended her Ph.D. Thesis Proposal, and she is now a Ph.D. candidate!

First NIH-NCI Grant!

Our lab was awarded an NIH-NCI R21 grant to develop and validate the pH(Low) insertion peptide (pHLIP) as a novel therapeutic for prostate cancer.