Welcome to the Thévenin Group Web Page
We are interested in understanding how transmembrane helix interactions in cell membranes modulate the activity of integral membrane proteins. Integral membrane proteins are involved in almost every aspect of cell biology and physiology. Consequently, proper functioning of these proteins is vital to health, and defects are associated with many known diseases. However, the structural features and mechanisms that govern signal transduction across cell membrane and oligomerization are not well known or described. Our research seeks to gain structural and mechanistic insights into the role of these interactions in normal physiological functions and diseases. We also seek to develop novel biomedical technologies targeting transmembrane interactions and the activity of cytoplasmic signaling proteins in cancer cells. The interdisciplinary nature of this work involves a wide range of biophysical, biochemical and biological approaches, and is collaborative. We work in close contact with the Engelman and the DiMaio Labs at Yale University.