Professor: Jeff Sands ( jas0@lehigh.edu )
This distance-only graduate course will consist of (1) background lectures and assignments on the molecular biology of virus replication and virus-host interactions, and (2) four early-2005 journal article presentations by each course participant. The only exam in the course will be at the end of the semester.
There is no required textbook. The lectures will be supplemented with web notes and links. We will make particular extensive use of links to research articles in journals such as Journal of Virology, Virology, Journal of General Virology, Journal of Infectious Diseases, PNAS, the Nature journals, Science, and some others. Other useful links include the CDC and the WHO.
Date and Topic
Jan. 17 Course Organization and Introduction
Jan. 24 Virus Structures and Entry Mechanisms
Jan. 31 Replication of DNA Genome Viruses (examples: Herpesviruses and Poxviruses)
Feb. 7 Replication of + and - ss RNA Genome Viruses (examples: Picornaviruses and Orthomyxoviruses)
Feb. 14 Replication of ds RNA Viruses (Reoviruses) and RNA-to-DNA Viruses (Retroviruses)
Feb. 28 Immune Response and Vaccines
Mar. 14 Five journal article presentations and Antiviral Drugs
( Judy presents Cheung et al., J. Gen Virol. 86: 131-138 (on C-terminus of HIV gp41)).
( Sharon presents Sullivan et al., J. Virol. 79: 547-553 (on Ebola glycoprotein toxicity)).
( Krista presents Cologna et al., J. Virol. 79: 853-859 (on selection for virulent Dengue)).
( Krista presents Zhao et al., Virology 331: 128-135 (on SARS-coronavirus DNA vaccine)).
( Judy presents Garcia-Robles et al., Virology 332: 329-336 (on flu protein int. with nucleosomes)).
Mar. 21 Three journal article presentations and Influenza Epidemiology.
( Elizabeth presents Carnec et al., J. Virol. 79: 1930-1933 ( on anti-CXCR4 antibodies)
( combined with Yi et al., J. Virol. 79: 1480-1486 ( on use of CXCR4 for HIV entry)).
( Sharon presents Gillgrasss et al., J. Virol. 79: 3107-3116 (on HSV-2, estradiol, and progesterone)).
Mar. 28 Two journal article presentations and Influenza Epidemiology (cont.).
( Sharon presents Wang and Sonenshein, J. Virol. 79: 95-105 (on CMV IE1 protein effects)).
( Judy presents Kallewaard et al., Virology 331: 73-81 (on cytoskeleton and RSV replication)).
Apr. 4 Two journal article presentations and HIV Epidemiology I.
( Elizabeth presents Roy et al., Virology 333: 207-214 (on use of adenoviral vectors)).
( Krista presents Wahl-Jensen et al., J. Virol. 79: 2413-2419 (on macrophages / Ebola gp & vlp)).
Apr. 11 Three journal article presentations and HIV Epidemiology II
( Sharon presents Naranatt et al., J. Virol. 79: 1191-1206 (on Kaposi's DNA delivery to nucleus)).
( Judy presents Stone et al., J. Virol. 79: 5090-5104 (on adenovirus 11 as a vector)).
( Elizabeth presents Wu et al., J. Virol. 79: 3382-3390 (on foreign peptides into adenovirus hexon)).
Apr. 18 Two journal article presentations and HIV Epidemiology III
( Elizabeth presents Seaman et al., J. Virol. 79: 2956-2963 (on HIV-1 envelope immunogens)).
( Krista presents Spink and Laimins, J. Virol. 79: 4918-4926 (on HPV late promoter induction)).
Any day starting April 25 to May 2: Take-home Exam ( Due seven days after start.)