Our group develops mathematical and computational models in the general area of cellular biophysics. Our motivation is to better understand the physical principles that underlie the function and internal organization of living cells over length scales larger than that of individual molecules.

We have an interest in the actin cytoskeleton. Networks and bundles of actin filaments spontaneously form subcellular structures with mechanical integrity that provide cells with shape, generate mechanical forces and movement by polymerization, and act as tracks for motor proteins.

In collaboration with biologists and computer scientists, we apply methods from statistical physics, soft matter physics, and nonlinear dynamics to study biological processes such as the function of the actomyosin contractile ring during cytokinesis and cell polarization for cell motion, mating, and growth.

We thank the sponsors of our research, NIH/NIGMS.