Dr.Liu Lab: Bio Nanomechanics, LU


Bio and Nanofluidics Laboratory:

Equipment available in Dr. Liu's laboratory includes
  • Two cell culture hoods and three cell incubators
  • Harvard Apparatus PhD 2000 programmable syringe pumps
  • Agilent Arbitrary Waveform Generator, Digital DC sourcemeter
  • Nikon Eclipse TE2000 inverted fluorescence microscope
  • Electrophysiology rig (including Newport MD-285 micromanipulator, Sutter Instrument ROE-200 Multi-Manipulator Controller, Warner Instrument SF-77B Perfusion Fast-Step, Automatic Temperature Controller, VC-6 six channel Valve Controller, Fluor Mechanic FV-10 pumps, Sutter Instruments Lambda 10-B microprocessor-controlled filter wheel, Intracellular Imaging 175 Watt Xenon Light Source, Axon Instruments 1322A 16-bit data acquisition system, Multiclamp 700B current and voltage clamp, TMC Vibration table, and Photometric coolsnap HQ2 camera)
  • Centrifuge, hot plate, refrigerators, freezers, PH meters, and analytical balances
  • Sutter Instrument P-97 Micropipette Puller, Narishige MF-830 Microforge
  • Glove box: The glove box used in our lab serves as an enclosed workspace equipped with gloved openings that allow for the manipulation of chemicals and devices within a closed environment. This special piece of protective equipment is used as a means of carrying out experimental procedures to which the individual should not be directly exposed to. The glove box also allows for experimental procedures to be carried out in the absence of oxygen; a key requirement when working with chemicals which are strong oxidizers. Glove boxes are made by many different companies, however the one used in our lab is produced by PLAS LABS located in Lansing, MI.
  • Ventilated hood box: The ventilated hood box in our laboratory is primarily used for the final stage of PDMS device fabrication. After the individual pieces of PDMS devices are prepared in the chemical hood, the final cleaning, corona treatment and bonding process occurs in the ventilated good box as to reduce the risk of dust particles from being sealed within the devices. This critical piece of equipment in our lab ensures that we are able to produce clean and well functioning PDMS devices for testing. The particular ventilated hood box used in our lab is produced by AirClean Systems.
  • 3d-printer: The 3d-printer in our lab is a stereolithography 3D Printer with 4.9"x4.9"x6.5" build volume, 300 microns minimum feature size, and 25 microns minimum layer thickness
  • Milling machine: The milling machine in our lab could reach a milling area of 3.39"x2.17"x1.02", 0.001 mm software resolution, and 0.000186 mmmechanical resolution
  • Dyne-A-Mite surface treater: The surface treater in our lab is used to increase surface energy and tension, enabling improved adhesion of inks, coatings, adhesives, and markings. The Dyne-A-Mite surface treater generates a blown arc of air plasma to treat surfaces
As a core faculty in Lehigh’s Bioengineering program, Dr. Liu’s group has access to Lehigh’s Bioengineering and Biology core facilities, which includes Veeco AFM, Zeiss LSM 510 META laser scanning confocal microscope, Olympus inverted fluorescence microscope, flow cytometer, Beckman ultra centrifugation, fluorometer and luminometer, probe sonicator, LVEM5 electron microscope, and cell culture facilities.

Cleanroom Facility:

Dr. Liu’s group has access to Lehigh’s Center for Advanced Materials and Nanotechnology as well as Lehigh’s Optical Center, which have a large range of state-of-the-art instruments and equipment for fabrication and characterization, maintained by dedicated staff. The ever increasing list of equipment includes AFM, electron microscopes, focused ion beam and e-beam writers, mask aligners, and standard silicon fabrication apparatus.

Computational Facility:

The Liu’s group currently has one 12-proccessor, 3.33 GHz Dell Xeon workstation and three 4-proccessor, 3.2 GHz HP workstations. The computational-extensive modeling work are usually performed using the parallel computing clusters at the High Performance Computing center in Lehigh University. Dr. Liu’s group also has computer accounts with NSF Teragrid Supercomputers (SDSC Intel Itanium2 IA-64, and NCSA Xeon Linux Supercluster, PSC Altix Cluster).

 Fig. 1: Part of our lab                    Fig. 2: Cell culture room
 Fig. 3:Layout of our office                    Fig. 4: Part of our office
 Fig. 5: Cell culture hood                    Fig. 6: Cell Incubators
 Fig. 7: Setup of fluorescence microscope           Fig. 8: Setup of flow test using programmable syringe pump
 Fig. 9: Glove box                         Fig. 10: Ventilated hood box
 Fig. 11: 3d-printer                         Fig. 12: Milling machine
 Fig. 13: Dyne-A-Mite surface treater

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