Publications Page

2011



"On the Nature of Oxidative Coupling of Lithium Enolates" Casey, B.M.; Flowers, R.A., II J. Am. Chem. Soc., 2011, 133, 11492–11495


"Catalytic Ni(II) in Reactions of SmI2: Sm(II)- or Ni(0)-Based Chemistry?" Choquette, K.A.; Sadasivam, D.V.; Flowers, R.A., II J. Am. Chem. Soc., 2011, 133, 10655–10661


"Backscattering Interferometry: an alternative approach for the study of hydrgen bonding interactions in organic solvents" Pesciotta, E.; Bornhop. D.J.; Flowers, R.A., II Org. Lett. 2011,13, 2654–2657


"Investigation of Anticholinergic and Non-steroidal Anti-inflammatory Prodrugs which Reduce Chemically-induced Skin Inflammation" Young, S.C.; Fabio, K.M.; Huange, M.-T.; Saxena, J.; Harman, M.P.; Guillon, C.D.; Heck, D.E.; Flowers, R.A., II; Heindel, N.D.; Laskin, J.D. J. Appl. Tox. 2011, 292,1-23


"A convenient pathway to Sm(II)-mediated chemistry in acetonitrile" Maisano, T.; Sadasivam, D.V.; Flowers, R.A., II Org. Biomol. Chem. 2011, 9, 1714-1716.


"Backscattering Interferometry: A Versatile Platform for the Study of Free-Solution vs. Surface Immobilized Hybridization" Pesciotta, E.; Bornhop. D.J.; Flowers, R.A., II Chemistry, As. J. 2011, 6, 70-73.


2010



"Uncovering the Mechanistic Role of HMPA in the Samarium Barbier Reaction" Choquette, K.A.; Sadasivam, D.V.; Flowers, R.A., II J. Am. Chem. Soc. 2010, 132, 17396-17398.


"Dynamic Ligand Exhange in Reactions of Samarium Diiodide" Teprovich, J.A., Jr.; Sadasivam, D.V.; Procter, D.J.; Flowers, R.A., II Org. Lett. 2010, 12, 4140-4143.


"Mechanistic Complexity in Organo-SOMO Activation" Devery, J.J., III; Conrad, J.C.; MacMillan, D.W.C.; Flowers, R.A., II Angew. Chem., Int. Ed. 2010, 49, 6106-6110.


“Selective Monovalent Cation Association and Exchange around Keplerate Polyoxometalate Macroanions in Dilute Aqueous Solution” Pigga, J.M.; Teprovich, J.A., Jr.; Flowers, R.A., II; Antonio, M.R.; Liu, T. Langmuir 2010, 26, 9449-9456.


“Peripheral Site Acetylcholinesterase Inhibitors Targeting Both Inflammation and Cholinergic Dysfunction” Young, S.; Fabio, K.; Guillon, C.; Mohanta, P. Halton, T.A.; Heck, D.E.; Flowers, R.A., II; Laskin, J.D.; Heindel, N.D. Bioorg. Med. Chem. Lett. 2010, 20, 2987-2990.


“Efficient protein renaturation using tunable hemifluorinated anionic surfactants as additives” Singh, R.; Flowers, R.A., II Chem. Commun. 2010, 46, 276-278.


Procter, D.J.; Flowers, R.A., II; Skrydstrup, T. Organic Synthesis Using Samarium Diiodide: A Practical Guide; Royal Society of Chemistry Publishing: UK, 2010. Book.


2009



“Synthesis of γ-substituted Ketones via the Ce(IV)-mediated Oxidative Coupling of Cyclobutanols and Inorganic Halides” Casey, B.M.; Eakin, C.A.; Flowers, R.A., II Tetrahedron Lett. 2009, 50, 1264-1266.


“Ce(IV)-Based Synthesis of Tetrasubstituted Pyrazoles” Devery, J.D., III; Mohanta, P.K.; Casey, B.M.; Flowers, R.A., II Synlett 2009, 1490-1494.


“Generation of Triarylamine Radical Cations Through Reaction of Triarylamines with Cu(II) in Acetonitrile. A Kinetic Investigation” Sreenath, K.; Suneesh, C.V.; Gopidas, K.R.; Flowers, R.A., II J. Phys. Chem. A 2009 113, 6477-6483. collaboration with Dr. Gopidas at NIIST, Trivandrum, India


“Studies on the Mechanism, Selectivity, and Synthetic Utility of Lactone Reduction Using SmI2 and H2O” Parmar, D.; Sadasivam, D.V.; Matsubara, H.; Bradley, P.A.; Flowers, R.A., II; Procter, D.J. J. Am. Chem. Soc. 2009, 131, 15467-15473. collaboration with David Procter, University of Manchester


“Solvent-Dependent Oxidative Coupling of 1-Aryl-1,3-dicarbonyls and Styrene” Casey, B.M.; Eakin, C.A.; Jiao, J.; Flowers, R.A., II Tetrahedron 2009, 65, 10762-10768.


2008



“Generation of Sm(II) Reductants Using High Intensity Ultrasound” Teprovich, J.A., Jr.; Antharjanam, P.K.S.; Prasad, E.; Pesciotta E. N.; Flowers, R.A., II Eur. J. Inorg. Chem. 2008, 5015-5019. Article featured on the journal cover.


"Mechanistic Study of Samarium Diiodide-HMPA Initiated 5-exo-trig Ketyl-Olefin Coupling: The Role of HMPA in Post Electron Transfer Steps" Sadasivam, D.V.; Antharjanam, P.K.S.; Prasad, E.; Flowers, R.A., II J. Am. Chem Soc. 2008, 130, 7228-7229. First paper to be featured as an Image Challenge on the new JACSβ website.


"Mechanistic Studies on the Role of Cosolvents and Additives in Samarium(II)-Based Reductions" Flowers, R.A., II Synlett 2008, 1427-1439. Invited Account of my work


2007



"Mechanistic Role of Proton Donor Coordination in Reactions of Samarium Diiodide" Teprovich, J.A., Jr.; Balili, M.N.; Pintauer, T.; Flowers, R.A., II Angew. Chem. 2007, 46, 8160-8163. VIP paper


"Mechanistic Studies of Ce(IV)-mediated Oxidation of 1,3-Dicarbonyls: Solvent-Dependent Behavior of Radical Cation Intermediates" Jiao, J.; Zhang, Y.; Devery, J.J.; Xu, L.; Deng, J.; Flowers, R.A., II J. Org. Chem. 2007, 72, 5486-5492.


"An Efficient and General Approach to β-Functionalized Ketones" Jiao, J.; Nguyen, L. X.; Patterson, D.R.; Flowers, R.A., II Org. Lett. 2007, 9, 1323-1326.


"Solvation Controlled Luminescence of Sm(II) Complexes" Teprovich, J.A., Jr.; Prasad, E.; Flowers, R.A., II Angew. Chem. 2007, 46, 1145-1148. VIP paper


2006



"A Convenient One-Pot Synthesis of Spirocyclic Pyrido[1,2-a]indole Derivatives from 3-(2-Bromoethyl)indole" Jiao, J.; Zhang, Y.; Flowers, R.A., II Synlett, 2006, 3355-3357.


“Mild Conversion of β-diketones to Carboxylic Acids by CAN” Zhang, Y.; Jiao, J.; Flowers, R.A., II J. Org. Chem. 2006, 71, 4516-4520.


"Mechanistic Evidence for Intermolecular Radical Carbonyl Additions Promoted by Samarium Diiodide" Hansen, A.M.; Lindsay, K.B.; Antharjanam, P.K.S.; Karaffa, J.; Daasbjerg, K.; Flowers, R.A., II; Skrydstrup, T. J. Am. Chem. Soc. 2006, 128, 9616-9617. collaboration with Troels Skrydstrup and Kim Daasbjerg, Aarhus University, Denmark.


“Stopped-Flow Kinetics of Tetrazine Cycloadditions: Experimental and Computational Studies Towards Sequential Transition States” Sadasivam, D.V.; Prasad, E.; Flowers, R.A., II; Birney, D.M. J. Phys. Chem. 2006, 110, 1288-1294. collaboration with David Birney at Texas Tech University.


“Samarium(II)-Based Reductants” Flowers, R.A., II; Prasad, E. Handbook on the Physics and Chemistry of Rare Earths, Eds. K.A. Gschneidner, Jr. J.-C,G, Bunzli, V.K. Pecharsky, Elsevier, 2006, Vol. 36, Chapter 230, pgs. 393-473. Book Chapter.


2005



"Reduction of β-hydroxyketones by SmI2/H2O/Amine " Davis, T.A.; Chopade, P.; Hilmersson, G.: Flowers, R.A., II Org. Lett. 2005, 7, 119-122.


“Photoinduced Electron Transfer Reactions by SmI2 in THF: Luminescence Quenching Studies and Mechanistic Investigations.” Chem. Eur. J. Prasad, E.; Knettle, B.W.; Flowers, R.A., II Chem. Eur. J. 2005, 11, 3105-3112.


“Exploring SmBr2, SmI2, and YbI2 Mediated Reactions assisted by Microwave Irradiation” Dahlén, A.; Prasad, E.; Flowers, R.A., II; Hilmersson, G. Chem. Eur. J., 2005, 11, 3279-3284. collaboration with Göran Hilmersson, Göteborg University, Sweden


“Chelation-Controlled Diastereoselective Reduction of α-Fluoroketones” Mohanta, P.K.; Davis, T.A.; Gooch, J. R.; Flowers, R.A., II J. Am. Chem. Soc. 2005, 127, 11896-11897.


"Cyclic Aromatic Oligoamides as Highly Selective Receptors for the Guanidinium Ion" Sanford, A.R.; Yuan, L.H.; Feng, W.; Yamato, K.; Flowers, R.A. II; Gong, B. Chem. Comm. 2005, 4720-4722. collaboration with Bing Gong, SUNY, Buffalo


“The Role of Water in SmI2-Mediated Reductions of Alkyl Halides” Prasad, E.; Flowers, R.A.., II J. Am. Chem. Soc. 2005, 127, 18093-18099.


2004



"The Role of Proton Donors in SmI2 Mediated Ketone Reduction: New Mechanistic Insights" Chopade, P.; Prasad, E.; Flowers, R.A., II J. Am. Chem. Soc. 2004, 126, 44-45.


“The Role of Ligand Displacement in Sm(II)-HMPA Based Reductions” Prasad, E.; Knettle, B.W.; Flowers, R.A., II J. Am. Chem. Soc. 2004, 126, 6891-6894.


“A Polymer-Supported Phosphoramide as a Lewis Base-Catalyst for the Catalytic Aldol Reaction” Flowers, R.A., II; Xu, X.; Timmons, C.; Li, G. Eur. J. Org. Chem. 2004, 2988-2990. collaboration with Guigen Li, Texas Tech University


“Solvent Dependent Diastereoselectivities in Reductions of β-Hydroxyketones by SmI2” Chopade, P.; Davis, T.A.; Prasad, E.; Flowers, R.A., II Org. Lett. 2004, 6, 2685-2688.


“Solvent Dependent Chemoselectivities in Additions of β-Carbonyl Imines to Allyl Trimethylsilane Using CTAN” Zhang, Y.; Raines, A.J.; Flowers, R.A., II J. Org Chem. 2004, 69, 6267-6272.


2003



"Rapid SmI2 Mediated Reductions of Alkyl Halides and Electrochemical Properties of SmI2/H2O/Amine" Dahlen, A.; Hilmersson, G.; Knettle, B.W.; Flowers, R.A., II J. Org. Chem. 2003, 68, 4870-4875.


"Mechanistic Investigation of Substrate Oxidation by Ce(IV) Reagents in Acetonitrile" Zhang, Y.; Flowers, R.A., II J. Org. Chem. 2003, 68, 4560-4562.


"Solvent Dependent Chemoselectivities in Ce(IV) Mediated Oxidative Coupling Reactions" Zhang, Y.; Raines, A.J.; Flowers, R.A., II Org. Lett. 2003, 5, 2363-2365.


"Reduction and Reductive Coupling of Imines by Sm(II)-Based Reagents" Kim, M.; Knettle, B.W.; Dahlen, A.; Hilmersson, G.; Flowers, R.A., II Tetrahedron 2003, 59, 10397-10402.


2002



"A Non-Covalent Approach to Anti-Parallel β-Sheet Formation" Zeng, H.; Yang, X,; Flowers, R.A., II; Gong, B. J. Am. Chem. Soc. 2002, 124, 2903-2910. collaboration with Bing Gong, SUNY, Buffalo


"Mechanistic Study of β-Substituent Effects on the Mechanism of Ketone Reduction by SmI2" Prasad, E.; Flowers, R.A., II J. Am. Chem. Soc. 2002, 124, 6357-6361.


"Reduction of Alkyl Halides and Ketones by SmI2 and Sm(II)-HMPA Complexes. Rate and Mechanistic Studies" Prasad, E.; Flowers, R.A., II J. Am. Chem. Soc. 2002, 124, 6895-6899.


"Protein Micelles from Lipoxygenase 3" Brault, P.-A.; Kariapper, M.S.T.; Pham, C.V.; Flowers, R.A., II; Gunning, W.T.; Funk, M.O., Jr. Biomacromolecules 2002, 3, 649-654. collaboration with Max Funk, University of Toledo


"Investigation of the [Sm{N(SiMe3)2}2] Reducing System in THF. Rate and Mechanistic Studies" Prasad, E.; Knettle, B.W.; Flowers, R.A., II J. Am. Chem. Soc. 2002, 124, 14663-14667.


"Molecular Clips that Undergo Self-Sorting and Heterochiral Aggregation" Wu, A.; Chakraborty, A.; Fettinger, J.C.; Flowers, R.A., II; Isaacs, L. Angew. Chem. 2002, 41, 4028-4030. collaboration with Lyle Isaacs, University of Maryland


2001



“Human Rad52 Protein Has Extreme Thermal Stability” Ranatunga, W.; Jackson, D.; Flowers, R.A., II; Borgstahl, G.E.O. Biochemistry 2001, 40, 8557-8562.


“Sequence Specificity of Hydrogen-Bonded Molecular Duplexes" Zeng, H.; Ickes, H.; Flowers, R.A., II, Gong, B. J. Org. Chem. 2001, 66, 3574-3583.


“Influence of HMPA on the Reducing Power and Reactivity of SmBr2” Knettle, B.W.; Flowers, R.A., II Org. Lett. 2001, 3, 2321-2324.


2000



"Highly Organized Spherical Hosts That Bind Organic Guest in Aqueous Solution with Micromolar Affinity: Microcalorimetry Studies" Piatnitski, E.L.; Deshayes, K.; Flowers, R.A., II Chem. Eur. J. 2000, 6, 999-1006.


"Electrochemical Investigation of the Solvolytic Properties of Ethylammonium Nitrate (EAN)" Shotwell, J.B.; Flowers, R.A., II Electroanalysis 2000, 12, 223-226.


"A Highly Stable, Six-Hydrogen Bonded Molecular Duplex" Zeng, H.; Miller, R.S.; Flowers, R.A., II; Gong, B. J. Am. Chem. Soc. 2000, 122, 2635-2644. collaboration with Bing Gong, SUNY, Buffalo


"SmI2-Mediated Nitrile Aldol Reaction" Caracoti, A.; Flowers, R.A., II Tetrahedron Lett. 2000, 41, 3039-3041.


“Guest and Subunit Exchange in Self-Assembled Ionophores” Cai, M.; Sidorov, V.; Lam, Y.-F.; Flowers, R.A., II; Davis, J.T. Org. Lett. 2000, 2, 1665-1668. collaboration with Jeff Davis, University of Maryland


"Inner-Sphere vs. Outer Sphere Electron Transfer in Reactions Mediated by Samarium(II)Iodide" Miller, R.S.; Sealy, J.M.; Fuchs, J.R.; Shabangi, M.; Flowers, R.A., II J. Am. Chem. Soc. 2000, 122, 7718-7722.


"Protein Renaturation by the Liquid Organic Salt Ethylammonium Nitrate (EAN)" Summers, C.A.; Flowers, R.A., II Protein Science 2000, 9, 2001-2008.


“Aggregation State and Reducing Power of the SmI2-DMPU Complex in Acetonitrile” Kuhlman, M.L.; Flowers, R.A., II Tetrahedron Lett. 2000, 41, 8049-8052.


1999



"The Influence of Cosolvent and Additives on the Reactivity of Samarium Diiodide" Flowers, R.A., II; Shabangi, M.; Caracoti, A.; Sealy, J.M. Recent Research Developments in Organic Chemistry 1999, 3, 141-149. Book Chapter


"Structure and Energetics of the Samarium Diiodide-HMPA Complex in Tetrahydrofuran" Shotwell, J.B.; Sealy, J.M.; Flowers, R.A., II J. Org. Chem. 1999, 64, 5251-5255.


"Ethylammonium Nitrate: A Protein Crystallization Reagent" Garlitz, J.A.; Summers, C.A.; Flowers, R.A., II; Borgstahl, G.E.O. Acta Cryst. D 1999, D55, 2037-2038.


"The Mechanism of Reduction of Primary Radicals by SmI2-HMPA" Shabangi, M.; Kuhlman, M.L.; Flowers, R.A., II Org. Lett. 1999, 1, 2133 -2135.


1998



"The Effect of Cosolvent on the Reducing Power of SmI2 in Tetrahydrofuran" Shabangi, M.; Sealy, J.M.; Fuchs, J.R.; Flowers, R.A., II Tetrahedron Lett. 1998 39, 4429-4432.


"Calorimetric Determination of the Solution Affinity of YbCl3 for HMPA in Tetrahydrofuran" Shotwell, J.B.; Flowers, R.A., II Tetrahedron Lett. 1998, 39. 8063-8066.


"Observation of Two-Mode Binding to DNA by Bipyridyl-(ethylenediamine) platinum(II): Isothermal Titration Calorimetry and Infrared Absorption Studies" Szabo, A.; Flowers, R.A., II; Carter, B.J.; Lee, S.A. Phys. Rev. E. 1998, 58, 7754-7760.


"Structural and Thermochemical Characterization of Lipoxygenase Catechol Complexes" Pham, C.; Jankun, J.; Skrzypczak-Jankun, E.; Flowers, R.A., II; Funk, M.O., Jr. Biochemistry 1998, 51, 17952-17957. collaboration with Max Funk, University of Toledo


1997



“Electrochemical Investigation of the Reducing Power of SmI2 and the Effect of HMPA Cosolvent” Shabangi, M.; Flowers, R.A., II Tetrahedron Lett. 1997, 38, 1137-1140.


“Structural Rearrangement of Strained Coals” Larsen, J.W.; Flowers, R.A., II; Hall, P.J.; Carlson, G. Energy & Fuels, 1997, 11, 998-1002


"9-Aryl-Xanthenes as Prototype Amphihydric Compounds for Relating the Stabilities of Cations, Anions, and Radicals by C-H Bond Cleavage and Electron Transfer" Arnett, E.M.; Flowers, R.A.; Ludwig, R.T.; Meekhof, A.E.; Walek, S. J. Phys. Org. Chem., 1997, 10, 499-513.




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