Facilities
- 30/250 liters computer controlled bioreactor facility with bio-separations/purifications support.
- Extensive fermentations capacity in batch and continuous culture, ranging from 0.5 to 30 liters.
- Mammalian and plant cell culture laboratories with comprehensive analytical support
Biopharmaceutical Technology Institute
Lehigh University-Mountaintop Campus
111 Research Drive
Bethlehem, PA 18015
(610) 758-4257/5427
The Biopharmaceutical Technology Institute presently occupies 3600 square feet of laboratory and 2250 square feet of pilot plant space in the C wing of Iaccoca Hall of the Mountaintop Campus. The institute is equipped with 30/250 liters of pilot-scale computer controlled bioreactors, monitored and controlled by Leeds & Northup MAZ 1 Distributed Digital Control Unit. In addition, numerous small-scale reactors are available for batch and continuous culture work. Key emerging monitoring systems used on the pilot-scale fermentation equipment include a UTI Quadropole Mass Spectrometer, BioChem Technology Fluromeasure System, and an ASI ReactIR 1000 FTIR Spectrophotometer with steam sterilizable DiCompTM probe. Pilot-scale separations capability is being developed and currently includes a Millipore Pellicon Unit, Sharples centrifuges and large-scale chromatography.
The fermentation and separations facilities are supported by analytical equipment and facilities including UV/visible spectrometers, isocratic and gradient HPLC's with refractive index and variable wavelength UV/visible detectors, gas chromatographs with FID and TCD detectors, YSI analyzer, Branson cell sonifer, incubator/shakers, laminar flow hood, microscopes, centrifuges and ultracentrifuges, scintillation and gamma counters, liquid and gas liquid chromatographs, high-field NMR, etc.
Mammalian cell cultivation is conducted in a recently constructed class 1000 laboratory equipped with CO2 incubators, vertical laminar flow hoods, a Bellco roller bottle apparatus, Millipore Milli-Q purification system, inverted microscope, etc.