Present Research Activities Anticancer drug screening from cDNA library Infrared spectroscopy for on-line monitoring Kinetics of growth and product formation by mammalian cell systems Development of strategies for bioreactor control and optimization Fundamentals of bioseparation systems. Continuous chromatography Aqueous two-phase extraction Affinity and metal-ligand chromatography Centrifugal precipitation chromatography      The research program of this institute is devoted specifically to the engineering and scientific fundamentals related to development, designs, validation, cGMP (current Good Manufacture Practice) operations, safety, monitoring, and control of fermentation, purification and product modification and formulation processes.      The research thrusts of the institute include: immunochemistry applied to clinical diagnostics; modification and use of monoclonal antibodies in radiosensitization and NMR imaging; structural analysis of glycoprotein pharmaceuticals; tumor image enhancement; medicinal chemistry; chemistry of biologically potent molecules; application of recombinant DNA technology to biopharmaceuticals production; fundamental kinetics of microbial, mammalian and plant cell and enzyme systems; design and scale-up bioreactor and bioseparation systems; development of instrumentation for the on-line monitoring of biological unit operations; development of novel separation and purification schemes for recovery of biologically active macromolecules, antigens, and antibodies; development of cGMP validation procedure for biopharmaceutical processes and products; and biopharmaceutical drugs research, design and delivery systems.      Specific examples of projects recently carried out within the institute are: development of Fourier transform infrared spectroscopy for the on-line monitoring of substrate, product and cell concentrations; kinetics of recombinant microbial and cell culture systems analysis of nutritional limitations and medium formulation for mammalian cell systems; use of cell cycle for enhancing mammalian cell culture productivity; fundamental studies of separation systems such as continuous chromatography, and aqueous two-phase extraction; plasmid DNA and recombinant protein purification; fundamental studies of protein conformation in bioprocessing by 2DFT1HNMR; perfusive effects in chromatographic separations; effect of cross-linking on biological activity; kinetics of enzyme production by cellulolytic fungi/actinomyceter; bioprocessing equipments cleaning and validation.