Professor Jeffrey A. Sands :email email@example.com
Department of Biological Sciences, Lehigh University
Note added in 2011: Here is the syllabus, with links to lecture outlines and problem solutions, that I used when I taught Genetics in the fall semester of 2005.
Prerequisites: The formal pre-requisite is Bio Core I: Cellular and Molecular. Beyond this, an additional informal pre-requisite for this course is that you be truly interested in studying the biological sciences.
Textbook and additional resources: The textbook for the course is Genetics: Analysis of Genes and Genomes, 6'th edition, 2005, by Hartl and Jones. Associated with this course is the one credit Genetics Laboratory course. Updated analyses on complete genomes of a variety of species are available at the Ensembl Genome Browser. The international journals Science, Nature, and Nature Reviews Genetics are excellent ways of keeping up with advances in genetics.
Lecture and Section Meetings: New material will be covered in lectures. Section meetings will be for questions, going over problems, and review.
Grading: There will be five exams ( 100 points each ), with the fifth (final) exam being able to count double and substitute for one of the first four exams. There will be no make-ups; if you miss an exam, that's the one that the final exam will replace.
Part One: Genes, Chromosomes, and Mendelian Inheritance
Aug 29 Introduction: Generation upon Generation
Aug. 31 Genotype to Phenotype Ch. 1 & 2, Problems S-1 & 1.18
Sept. 2 Inheritance, Darwin, and Mendel Ch. 1 & 2, Problems 2.8 & 2.12
Sept. 5 Fundamental Mendelian Genetics Ch. 3, Problems 3.4, 3.8, & 3.12.
Sept. 7 More Mendelian Genetics Ch. 3, Problems 3.14, 3.16, & 3.22.
Sept. 9 Chromosomes in Mitosis and Meiosis Ch. 4, Problems S-2, S-3, & 4.6.
Sept 12 Sex Chromosomes & X-Linked Inheritance Ch. 4, Problems 4.16, 4.17, & 4.20
Sept 14 Probability/Statistics in Inheritance Ch. 4, Problem S-4.
Sept 16 Solutions to Problems S-1 through S-4
Sept 19 Question/Answer Opportunity
Sept 21 EXAM 1. Overall results (class average and rough letter grade ranges) are listed here .
Part Two: Recombination and Chromosomal-Genome Analyses
Sept 23 Crossing-Over & Recombination Frequency I Ch. 5
Sept 26 Crossing-Over & Recombination Frequency II Ch. 5, Problems S-5 & S-6.
Sept 28 Chromosomal Maps & Mapping Functions Ch. 5, Problem S-7.
Sept 30 The Human Genome: Karyotypes & Variations I Ch. 8, Problem 8.6
Oct. 3 The Human Genome: Karyotypes & Variations II Ch. 8, Problems 8.8 & 8.16
Oct. 5 Comparison of Human & Chimpanzee Genomes
Oct. 7 Question/Answer Opportunity Solutions to Problems S-5, S-6, S-7
Oct. 12 EXAM 2. Overall results (class average and rough letter grade ranges) are listed here .
Part Three: Gene Expression and Regulation
Oct. 14 Gene Expression I: In the Nucleus Ch. 10, Problem 10.10
Oct. 17 Gene Expression II: In the Cytoplasm Ch. 10, Problem 10.26
Oct. 19 Regulation I: Initiation of Transcription Ch. 11, Problem S-8
Oct. 21 Regulation II: Processes in Eukaryotes Ch. 11, Problem S-9
Oct. 24 Regulation III: Programmed DNA Rearrangements Ch. 11, Problem S-10
Oct. 26 Transgenics Ch. 12, Problem 12.22
Oct. 28 Functional Genomics Ch. 12
Oct. 31 Question/Answer Opportunity. Solutions to Problems S-8, S-9, S-10
Nov. 2 EXAM 3 . Overall results (class average and rough letter grade ranges) are listed here .
Part Four: New Alleles, Populations, and Evolution
Nov. 4 Mutations and New Alleles I Ch. 14
Nov. 7 Mutations and New Alleles II Ch. 14
Nov. 9 Example Gene: Alleles of CFTR Ch. 14, Problem S-11
Nov. 11 Population Genetics in Equilibrium Ch. 17, Problem S-12
Nov. 14 Population Genetics with Evolutionary Change Ch. 17, Problems 17.10, 17.12, 17.14
Nov. 16 ( Completion of Nov. 14 lecture material. )
Nov. 18 Question/Answer Opportunity Solution to Problem S-11
Nov. 21 EXAM 4. Overall results (class average and rough letter grade ranges) are listed here .
Part Five: Complex Traits, Updates, and Perspectives
Nov. 28 Genetics of Complex Traits Ch. 18
Nov. 30 Medical Genetics Perspective ( by Dr. Larry Dennis, M.D.)
Dec. 2 Some "Why" Questions about the Genetic Code
Dec. 5 Review and 4'th 2005 Update: "A haplotype map of the human genome"
Dec. 7 Review and 4'th 2005 Update (continued)
Dec. 9 An End-of-Journey Perspective
The Final Exam on December 18 will be in Packard Auditorium (101) and start at 9 AM. It will be the same length and format as the previous exams, and thus should take about one hour. You may have as much of an additional hour (10 to 11 AM) as you wish.
Dec. 18 EXAM
5 ( FINAL EXAM ): ( 10-15% from part 5 and 85-90% from parts 1-4 ). Starts at 9 AM.