Bifunctional Anti-inflammatory and Anti-cholinergic Pro-Drugs as Potential Therapeutics for Sulfur Mustard-Induced Blisters
Sherri Young
Department of Chemistry
Abstract
A variety of lipophilic pro-drugs of diclofenac, naproxen, indomethacin and ibuprofen has been synthesized and screened for activity against chloroethyl ethyl sulfide (CEES) and tetradecanoylphorbol-13-acetate (phorbol ester) induced chemical injury. These unsymmetrical alkyl-aryl carbonates dually inhibit acetylcholinesterase (AChE) action and release an NSAID upon hydrolysis to treat inflammation more effectively than NSAIDs alone. The combination of lipophilicity, efficacy and stability of these bifunctionals make them attractive topical agents.
Bio: Sherri Young is a second year chemistry graduate student. Sherri is primarily doing organic synthesis for Dr. Ned Heindel and Dr. Robert Flowers. She graduated from Albright College in 2007 with a B.S. in chemistry and is excited to expand her chemistry knowledge.
