Sister chromatid cohesion is essential to cell viability
Marie Maradeo
Department of Biological Sciences
Abstract
Genome fidelity and cell fitness relies on a system that ensures that each daughter cell obtain a single copy and only a single copy of every chromosome while maintaining genomic integrity through repair processes. Sister chromatid cohesion tethers replicated DNA from S phase until cell division. Here, we document that DNA replication and repair factors contribute to proper chromosome pairing and segregation through interactions with cohesion genes.
Bio: Marie Maradeo is a 5th year graduate student in the Molecular Biology program. She works under the direction of Dr. Robert Skibbens and is studying the role DNA replication and repair factors contribute to genomic integrity. Currently, Marie is training and mentoring an Emmaus High School student. This semester Marie was awarded a Nemes Fellowship to continue her research. During her 5 years at Lehigh Marie has been extremely active in the Graduate Student Senate, holding two consecutive Executive Board positions and now serving as a Biology Department Representative. Marie is also an Editor for the Graduate Research Review.
