Chemical and Biomolecular Engineering Home > News > Dr. Kelly Schultz publishes a paper in the Proceedings of the National Academy of Sciences

Dr. Kelly Schultz publishes a paper in the Proceedings of the National Academy of Sciences reporting on the interaction of human mesenchymal stem cells with hydrogels

Dr. Kelly Schultz, Assistant Professor of Chemical and Bimolecular Engineering, recently published a paper (with co-authors Kyle A. Kyburz, and Kristi S. Anseth), entitled "Measuring dynamic cell–material interactions and remodeling during 3D human mesenchymal stem cell migration in hydrogels", in the Proceedings of the National Academy of Sciences (PNAS), in the July 6, 2015 issue.

The work uses microrheological characterization to measure 3D encapsulated human mesenchymal stem cell interactions with a synthetic hydrogel scaffold. This is the first study reporting real-time measurements of cell-mediated remodeling of their microenvironment. Being unable to measure cell-material interactions has been a critical missing link to understanding the outside-in signaling a cell experiences during motility. The published work finds that cells inhibit degradation directly around it to enable spreading and adhesion until these cells become motile. This measured phenomena is the opposite of the generally accepted view in the field of how a cells interacts and remodels it's environment.

PNAS, the principle journal of the National Academy of Sciences, is one of the world's most-cited and comprehensive multidisciplinary scientific journals, publishing more than 3,800 research papers annually. Established in 1914, PNAS publishes cutting-edge research, science news, Commentaries, Reviews, Perspectives, Colloquium Papers, and actions of the National Academy of Sciences

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