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CHM 456 SPECTRAL ANALYSIS (Spring 2006)
Goal:
(1.) To explain how to how find review papers about MALDI-MS ("matrix-assisted laser desorption ionization-mass spectrometry") and papers about *specific* applications of MALDI-MS to a chemical, clinical, or pharmaceutical problem.
For this purpose, please start with Web of Science ("WOS") or SciFinder Scholar ("SFS"). If you are off-campus, you may find WOS easier to access (details later) than SFS. If you have trouble finding what you need using one of these, try the "Other Science Databases" identified below.
(2.) To explain how to search both for scientific articles related to sports drug testing but also to find articles that provide an explanation understandable by a non-scientist of the techniques used and the problems solved.
TABLE OF CONTENTS
WHAT IT IS
A library database that lets you:
1. search for literature about a given subject, 1993-forward
2. start with a known paper (can be pre-1993) and find papers 1993 and later that cite it.
ACCESS
Web of Science (hereafter, WOS) is available off the library listing of databases. Select on-campus or off-campus depending on where you are. If you are off-campus, you will be prompted for your Lehigh login and ID.
In addition to reading below, also look at this tutorial.
When you are new to a field, it helps to begin by finding "review" papers that give you an overview of a field. By virtue of being "reviews", these papers can lead you to other papers.
To find articles that provide a "review" perspective of aspects of MALDI, go to WOS. Click on general search. Enter your search term string: in this case, try putting in: maldi or matrix-assisted laser desorption ionization. After putting in the search string, select "review" at the place where it says to "Restrict search by languages and document types ". NOTE: You do not have to do the restriction to review papers indicated here. That is, you can just run the afore-mentioned search without restricting in this way. However, if you come up with too many results and just want review papers, use this restriction.
The screen should look like this:
Notice that we've put in both "maldi" and the full phrase "matrix-assisted laser desorption ionization". Also, we did not put in "maldi-ms". Searching the acronym 'maldi' picks up everything that would be picked up by 'maldi-ms'.
Now click on "search". A list of titles comes up containing review articles. A portion of the list appears as follows:
Scroll through these to find one that of interest to you. Click on ones that interest you to see their full WOS record. An example of a record that comes up in this search is:
This is *not* the full text of an article; it provides information *about* an article, including an abstract. How do you get to the full text of the article?
Click on the link (partially clipped in above screen shot) that looks like this: 
This will bring up the SFX interface, which will (in this case) let you access the full text of the article.
In this case, the full text is available electronically. If you find, using SFX, that it is not available electronically, then off the SFX screen you can access ASA, Lehigh's online catalog, to see if it is available in print at Lehigh. (For further information about obtaining articles, see below).
Note: if you have gotten to this point and *not* found what you need, you may also try the following search string, which uses some 'advanced' features: the truncator * and the operator "same": maldi or matrix assis* same mass spectrom* . Click on WOS's help documentation for details and examples. If you still have difficulties, please contact the science librarian any time for assistance. Contact information is provided below.
FINDING ADDITIONAL PAPERS
If you decide that you are interested in the general topic covered by the paper just brought up, how can you find additional papers about this topic? Suppose that you're also interested in limiting the results to a specific time, say for example 2002-2006.
There are a few techniques to find papers that satisfy these criteria.
(i.) One method is to go back to the Annual Review of Biochemistry paper above, which is from 2001, and click on the links for "times cited". This will let you find items published later in time that cite the paper. This is a great way to locate a group of papers that deal with the same subject matter. (If you have no date restrictions, you can also click on "cited references" to find earlier papers).
(ii.) You can also do a date restriction to the period 2002-2006. Then, click on the "general search" button. Redo your search, but this time add a concept that focuses the search, such as "protein". Put in " protein* ", where the asterisk performs truncation. Also, don't restrict your search this time to "review".
(iii) Yet another method to bring up papers about the particular topic you are interested in: when you find an item you like, click on the related records button, which appears in records like the one above.
OTHER SEARCH TECHNIQUES FOR THE UNDAUNTED
Finally, supposing you already know that an author is an important one for the field you are searching, you can type in the author's name in the author search area of the general search screen. OR, if you already know a good paper (including ones that you found using another database), you can use the cited reference search capabilities of WOS. Click on the Cited Ref button.
For information, see here. SciFinder Scholar allows you to access a number of databases, including (most importantly) Chemical Abstracts, and MedLine (see below for other ways to access MedLine).
Persons off-campus may find it significantly easier at this point to use WOS. Whether you are on or off-campus, see here for information about accessing SciFinder Scholar 2006.
SciFinder Scholar and Science Citation Index are only two of the databases that Lehigh's libraries make available. Some other databases to check are these (clicking on the link brings you details about the database):
SPORTS DRUG TESTING: SCIENTIFIC PAPERS AND POPULAR BACKGROUND INFORMATION
This exercise has two components.
I.Scientific papers
One is to find scientific papers that deal with the same subject matter as this article:
G.T. Trout and R. Kazlauskas, Sports drug testing--an analyst's perspective, Chem. Soc. Rev., 2004, 33(1), 1-13.
For this purpose, try Web of Science, discussed above. Try doing a subject search on this topic but also try finding papers that cite this paper by using the cited reference capability at this webpage. ALSO: try PubMed. PubMed Gives access to Medline, a core resource for medical/biomedical topics, and one that is publicly available over the web. **Make sure you use Lehigh's link for this (click here) so that you can use the SFX-enabled version.**
For PubMed coverage, see here.
See these tutorials about searching PubMed. ***It's worth spending the time to learn how to use the "controlled vocabulary" available on PubMed.*** These are called MeSH headers. You can search them by going to the "MeSH Database" link off the PubMed home screen. (It appears under "PubMED Services" about midway down on the left.) To learn how to use these, see the tutorials about PubMed's MeSH Database available at the link just indicated or available off the MeSH header search area.
Note: there is another flavor of Medline here.
II. Popular Background Information
There are many resources you can consult for popular level, background level information about sports drug testing. Here are just a few:
Also, drag down here the subject menu for "social sciences" in the upper left. Check with the science librarian for further ideas and help in searching relevant resources.
At any point in your research, email the Science Librarian, Brian Simboli, if you have any questions. You may also call him at 610-758-5003 or drop by his office at Room 633 in Fairchild-Martindale Library. On Tuesday afternoons he is usually in the consulting office behind the help desk on the first floor of the library.