Graduate Courses in Chemistry
CHM 400. Laboratory
Safety (0) fall
Accident prevention; emergency response; government regulations;
facilities for handling and storage disposal of hazardous materials; emergency
facilities; liabilities. Lectures, multi-media presentations, hands-on
training by practitioners.
CHM 402. Physical Inorganic
Chemistry (3) alternate years
Aufbau principle and coupling of angular momenta is used to
describe atomic and molecular term states. Group theoretical principles
will be utilized in studies of molecular orbital and ligand field theories
of bonding. Prerequisite: CHM 341 or equivalent.
CHM 403. Advanced Topics
in Inorganic Chemistry (1-3) alternate years
Topics of contemporary interest in inorganic chemistry. This
course may be repeated when a different topic is offered. Prerequisite:
CHM 307 or equivalent.
CHM 405. Organometallic
Chemistry (3) alternate year
The chemistry of compounds containing
carbon to metal bonds. Among the topics covered are the following:
organic compounds of the representative elements from Group I to IV; the
chemistry of ferrocene and related pi-bonded organometallic complexes;
metal carbonyl and nitrosyl complexes; dioxygen and dinitrogen complexes;
organic synthesis utilizing organometallic catalysts.
CHM 411. Teaching Internship
(3-6) fall-spring
The preparation, teaching and grading of one or two undergraduate
lecture courses with appropriate supervision by senior faculty members.
Observation and evaluation of the intern is effected by classroom visits
and videotape review. Prerequisite: candidacy in the doctor of arts program
or permission of the department chair. May be repeated for credit.
CHM 421. Chemistry
Research (1-6)
Research in one of the following fields of chemistry: analytical,
inorganic, organic, physical, polymer, biochemistry. Link
to sample research reports, theses, and dissertations.
Link
to Electronic Library Resources for Chemists.
CHM 423. Bio-organic
Chemistry (3) alternate years
An examination of biochemistry on the basis of organic chemical
principles. Emphasis on reaction mechanisms of biochemical transformations
and methods for elucidation of these mechanisms, i.e., kinetics, isotope
effects, exchange techniques, inhibition studies, substrate analog effects
and organic model studies. Prerequisite: CHM 358.
CHM 424. Medicinal
and Pharmaceutical Chemistry (3) alternate years
Principles of drug design, structure-activity relationships
in antibacterial, antimalarial, anti-inflammatory and psychoactive drugs;
synthesis and modes of action of pharmacologically active agents radioactive
pharmaceuticals. Prerequisite: one year of organic chemistry.
CHM 425. Pharmaceutical
Regulatory Affairs 1: Drug Discovery to Approval (3)
Coverage includes the stages of
the drug approval process and how these relate to the laboratory activities
that provide the scientific basis of the New Drug Application (NDA). Lectures
treat drug discovery, chemical process development of the active pharmaceutical
ingredient (API), and pharmaceutical process development of the drug product.
Regulatory issues in screening and testing, the management of the preclinical
trials, and the management of clinical trials will be covered.
CHM 428. Pharmaceutical
Regulatory Affairs 2: Medical Devices and Combination Technologies: Concept
to Commercialization (3)
This course will review the history
of medical device law and regulations in the United States. It will also
define current requirements of science needed to allow technologies to
be developed according to regulations. Case studies will be used to educate
participants on Design Controls, Quality System Regulations, Manufacturing
Requirements and International Harmonization. Specifics may include Nucleic
Acid Diagnostics, Cardiovascular Stents, Drug Delivery, Cancer Diagnostics,
and Consumer Self-Testing.
CHM 430. Chemical and
Biochemical Separations (3) spring, alternate years
Theory and applications of equilibrium and nonequilibrium separation
techniques at both the analytical and preparative levels. Solvent and
buffer extractions, chromatographic separations (e.g., thin layer, partition,
gas liquid, gel filtration, ion exchange, affinity, supercritical fluid),
electrophoretic separations (e.g., gel, capillary, isoelectric focusing,
immunoelectrophoresis), centrifugal separations (e.g., differential, velocity
sedimentation, density gradient) and other separation methods (e.g., dialysis,
ultrafiltration). Examples will focus on biological applications.
CHM 431. Contemporary
Topics in Analytical Chemistry (1)
Discussion of the current literature in analytical chemistry,
including spectroscopy, separations, and electrochemistry. Students find
current papers and lead discussions. May be repeated for credit.
CHM 432. Chemometrics
(3) fall, alternate years
Mathematical and statistical methods for experimental design,
calibration, signal resolution, and instrument control and optimization.
CHM 433. Electroanalytical
Chemistry (3) alternate years
Theory and applications of selected electrochemical techniques;
solutions to mass transport problems, treatment of electron transfer kinetics
and kinetics of associated chemical reactions, and critical evaluation
of adsorption and other factors associated with electrochemical processes.
Prerequisite: CHM 332 or equivalent.
CHM 434. Advanced Topics
in Spectroscopy (3) fall, alternate years
Fundamentals of interactions of electromagnetic radiation with
matter: electronic, vibrational, scattering based spectroscopies, instrumentation
and signal processing. Advanced applications to the analysis of molecular
structure and chemical processes including surface analysis, time-resolved
spectroscopies, and ultrasensitive spectroscopic techniques.
CHM 436. Special Topics
in Analytical Chemistry (1-3)
Topics of contemporary interest in analytical chemistry. May
be repeated for credit when a different topic is offered.
CHM 437. (BioS 437)
Pathophysiological Chemistry (3) spring
Biochemical basis of human diseases involving abnormal metabolism
of proteins, nucleic acids, carbohydrates, and lipids. Emphasis on the
correlation of the clinical presentation of disease processes seen as
physiological dysfunctions with clinical laboratory methods. Lectures,
student presentations, and clinical case discussions. Prerequisite: consent
of the department chair.
CHM 441. Chemical Kinetics
(3) alternate years
A study of kinetic processes. Phenomenological chemical kinetics;
order, mechanism effect of external variables on rate. Theories of the
rate constant. Relation between thermodynamics and kinetics. Applications
to selected systems such as unimolecular decompositions, molecular beams
and diffusion-limited processes. Prerequisite: one year of physical chemistry.
CHM 442. Pharmaceutical
Regulatory Affairs 3: Analytical Methods, Validation, and Data Manipulation
(3)
A review of the FDA guidance and
common industry practices. A presentation of the more user-friendly and
higher accuracy analytical methods, which are supplanting traditional
analyses. Lectures will cover the eight fundamentals of analytical method
validation: accuracy, linearity, precision, limits of detection, selectivity,
limits of quantification, specificity, and ruggedness of method. In addition,
the student will be taught what to do when the results do not meet the
Acceptance Criteria. Lectures also cover evaluation of data streams for
supporting conclusions
CHM 443. (Mat 443)
Solid-State Chemistry (3) alternate years
Crystal structure, diffraction in crystals and on surfaces,
bonding and energy spectra in solids dielectrics, surface states and surface
fields in crystals. Prerequisite: one course in linear algebra and one
course in quantum mechanics.
CHM 445. Elements of
Physical Chemistry (4)
Quantum chemistry of simple systems, molecular structure and
spectroscopy, statistical and classical thermodynamics. Prerequisite:
CHM 341 or its equivalent.
CHM 451. Physical Organic
Chemistry (3) alternate years
An introduction to quantitative
organic chemistry including relationships between structure and reactivity,
medium effects on reactions, introduction to orbital symmetry effects
in organic reactions, and reaction mechanisms. Prerequisite: CHM 358 or
consent of department chair.
CHM 453. Heterocyclic
Compounds (3) alternate years
An intensive study of the syntheses, reactions and properties
of heteroaromatic compounds including derivatives of thiophene, pyrrole,
furan, indole, pyridine, quinoline, the azoles and the diazines - all
considered from the viewpoint of modern theories of structure and reaction
mechanisms. Prerequisite: CHM 358.
CHM 455. Organic Reactions
(3) alternate years
Intensive survey of modern synthetic organic chemistry from
a mechanistic standpoint. Classical Name-reactions, olefin synthesis,
organometallic reagents in synthesis, Woodward-Hoffmann rules, electrocyclic
processes, enolate chemistry, and related reactions. Prerequisite: CHM
358.
CHM 456. Spectral Analysis
(3) fall
Use of data from nuclear magnetic resonance, infrared, ultraviolet,
and mass spectrometric techniques for the determination of structure of
organic compounds. Emphasis on information from one- and two-dimensional
proton and carbon NMR, and a mechanistic interpretation of data from mass
spectrometry.
CHM 457. Organic Reaction
Mechanisms (3)
Intensive in-class problem solving that involves the formulation
of reasonable reaction mechanisms for complex multistep pathways, i.e.
organic transformations that proceed via highly energetic intermediates
such as carbocations, carbanions, free radicals, carbenes, and nitrenes.
CHM 458. Topics in
Organic Chemistry (1-3)
An intensive study of limited areas in organic chemistry. May
be repeated when a different topic is offered.
CHM 463.
Pharmaceutical Regulatory Afairs 4: Commercial Production, Validation,
and Process Qualification (3)
This course covers the scientific
principles and the registry requirements for polymeric implants, controlled-release
drug depot units, pumps, point-of care testing kits, contrast media for
MRI, x-ray, and ultrasound and all FDA controlled products not defined
as therapeutic pharmaceuticals.
CHM 466. Advanced Organic
Preparations (2-3)
A laboratory course of instruction in advanced techniques of
the preparation of organic compounds.
CHM 469. (BioS 469)
Biochemical Problem Solving I (1) fall
Applications of material covered in BioS/CHM 371 including techniques
used in research. Prerequisite: BioS/CHM 371 previously or concurrently.
CHM 470. (BioS 470)
Biochemical Problem Solving II (1) spring
Applications of concepts covered in BioS/CHM 372 including techniques
used in research. Prerequisite: BioS/CHM 372 previously or concurrently.
CHM 471. (BioS 471)
Eucaryotic Biochemistry (3) alternate years
Biochemistry of selected eucaryotic processes including hormone
chemistry, blood clotting, immunochemistry, vision chemistry, muscle chemistry
and photosynthesis. The second part of the course will involve presentation
and discussion of the current literature by class participants. Prerequisite:
BioS/CHM 372 or consent of department chair.
CHM 472. (BioS 472)
Lipids and Membranes (3) alternate years
Structure, physical properties and functions of lipids and their
biological aggregates. Techniques for studying lipid assemblies, enzymes
which act on lipids, membrane proteins and lipoproteins will also be discussed.
Prerequisite: BioS/CHM 372 or consent of department chair.
CHM 473. (BioS 473)
Biochemistry of Complex Carbohydrates (3) alternate years
Consideration of the structure, function and metabolism of complex
carbohydrates (glycolipids, glycoproteins and proteoglycans) with particular
emphasis on glycoproteins. The first part of the course will consist of
lectures to familiarize the student with basic terms, concepts and processes.
The second part will involve critical readings, presentation and discussion
of the current primary research literature by class participants.
CHM 475. Advanced Topics
in Chemistry (1)
Audiovisual courses in topics such as acid-base theory, NMR,
chromatography, electroanalytical chemistry and mass-spectroscopy interpretation;
course material obtained from the American Chemical Society. May be repeated
for credit.
CHM 477. (BioS 477)
Topics in Biochemistry (1-3)
Selected areas of biochemistry, such as mechanisms of enzyme
action, new developments in the chemistry of lipids, nucleic acids, carbohydrates
and proteins. May be repeated for credit when different topics are offered.
Prerequisite: consent of the department chair.
CHM 479. (BioS 479)
Biochemical Techniques (3)
Laboratory studies of the techniques and principles involved
in the isolation, identification, and biochemical transformation of carbohydrates,
lipids, nucleic acids and proteins. Prerequisite: CHM 371 or its equivalent
previously or concurrently.
CHM 480. (BioS 480)
Advanced Biochemical Preparations (1-3)
An advanced laboratory course
in the preparation, isolation, purification, and identification of biochemically
produced materials. Emphasis is placed on materials and procedures of
current interest in biochemistry. Prerequisite: consent of the department
chair.
CHM 481. Chemistry
Seminar (1)
Student presentations on current research topics in the student's
discipline but not on subjects close to the thesis. A one-hour presentation
and attendance at other presentations are required for credit. May be
repeated for credit, up to six times.
CHM 482. (ChE 482,
Mat 482) Engineering Behavior of Polymers (3) spring
Mechanical behavior of polymers. Characterization of experimentally
observed viscoelastic response of polymeric solids with the aid of mechanical
model analogs. Topics include time-temperature superposition, experimental
characterization of large deformation and fracture processes, polymer
adhesion, and the effects of fillers, plasticizer, moisture, and aging
on mechanical behavior.
CHM 483. (ChE 483)
Emulsion Polymers (3) fall
Fundamental concepts important in manufacture, characterization,
and application of polymer latexes. Topics include colloidal stability,
polymerization mechanisms and kinetics, reactor design, characterization
of particle surfaces, latex rheology, morphology considerations, polymerization
with functional groups, film formation and various application problems.
Prerequisite: previous course in polymers.
CHM 484. (ChE 484)
Crystalline Polymers (3) spring
Morphology and behavior of both polymer single crystals and
bulk crystallized system. Relationship between basic crystal physics,
thermal and annealing history, orientation and resulting properties. Thermodynamics
and kinetics of transition phenomena and a brief treatment of hydrodynamic
properties and their relationship to crystallization and processing properties.
CHM 485. (ChE 485,
Mat 485) Polymer Blends and Composites (3) fall
Synthesis, morphology and mechanical behavior of polymer blends
and composites. Mechanical blends block and graft copolymers, interpenetrating
polymer networks, polymer impregnated solids and fiber and particulate-reinforce
polymers are emphasized. Prerequisite: any introductory course in polymers.
CHM 487. Topics in
Colloid and Surface Chemistry (3)
Applications of colloid chemistry; special topics in surface
chemistry. Lectures and seminar. May be repeated for credit as different
topics are covered. Prerequisite: CHM 391.
CHM 488. Advanced Topics
in Physical Chemistry (1-3)
Advanced topics in physical chemistry, such as photochemistry
and molecular beam dynamics, Fourier transform spectroscopy, kinetics
of rapid reactions, theory of magnetic resonance, liquids and solutions.
May be repeated for credit when different topics are offered.
CHM 489. Organic Polymer
Science II (3) alternate years
Continuation of CHM 394. Theory and mechanism of ionic vinyl-addition
chain-growth polymerization. Chain copolymerization by radical and ionic
mechanism. Mechanism of ring-opening polymerization, stereochemistry of
polymerization including ionic, coordination, and Ziegler-Natta mechanisms.
Reactions of polymers, including crosslinking, reaction of functional
groups, graft and block copolymers, and polymer carriers and supports.
Prerequisite: CHM 394 or equivalent.
CHM 491. Physical Chemistry
of Organic Polymer Coatings (3) alternate years
Pigment/bonder geometry. Oil absorption of pigments. Critical
Pigment Volume Concentration concept. Pigment dispersion including surface
tension, capillarity, works of dispersion, transfer and flocculation,
and dispersing-mixing equipment. Solubility parameter concept. Coating
viscosity and viscometers. Evaporation of solvents including water. Coating
rheology, mill base letdown, and pigment settling. Film application including
leveling, sagging, slumping and draining. Prerequisite: CHM 393 or 394
or equivalent.
CHM 492. (ChE 492)
Topics in Polymer Science (3)
Intensive study of topics selected from areas of current research
interest such as morphology and mechanical behavior, thermodynamics and
kinetics of crystallization, new analytical techniques, molecular weight
distribution, non-Newtonian flow behavior, second-order transition phenomena,
novel polymer structures. Credit above three hours is granted only when
different material is covered. Prerequisite: CHM 392 or equivalent
CHM 493. Organic Chemistry
of Organic Polymer Coatings (3) alternate years
Film information from solution and dispersion, and application
of coatings. Mechanism and kinetics of curing glyceride oils, varnishes
and alkyd resins, unsaturated polyesters, thermoplastics cellulose, acrylic
and vinyl resins, epoxy resins, polyurethanes, amine- and phenol-formaldehyde
resins, thermosetting vinyl and acrylic copolymers, water-based systems,
natural and synthetic rubber, and silicone resins. New solutions coatings.
Prerequisite: CHM 393 and 394 or equivalent.
CHM 494. Quantum Chemistry
(3) alternate years
Principles and applications of quantum mechanics to chemical
problems. Applications to chemical bonding, molecular structure, reactivity
and spectroscopy. Prerequisite: CHM 445 or consent of the department chair.
CHM 495. Statistical
Thermodynamics (3) alternate years
Principles and applications of statistical mechanics to chemical
problems. A study of the techniques for evaluating the properties of matter
in bulk from the properties of molecules and their interactions. Prerequisite:
CHM 445 or consent of the department chair.
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