Research
Interests:
The general interest is on what role the covalently-bound
carbohydrate
on glycoproteins has on the structural and
functional
properties of these molecules in health and in disease. More specifically,
I am interested in 1) the role of the aspartyl protease cathepsin
D in the development and progression of breast cancer, and 2) the
role of the enzyme alpha-L-fucosidase in sperm/egg interactions
and fertilization in mammals.
Teaching
Interests:
I
teach undergraduate and graduate courses in the general areas of
biochemistry and analytical chemistry. Specialty courses are on
complex carbohydrates (chm 473), pathophysiological chemistry (chm
437), and separation chemistry (chm 430).
Selected
Publications:
S.
Khunsook, B. Bean, S. McGowan and J. A. Alhadeff
(2003). Purification and characterization
of plasma membrane-associated human sperm alpha-L-fucosidase,
Biol. Reproduction , 68:709-716.
S.
Khunsook, J.A. Alhadeff and B. Bean (2002). Purification
and characterization of
human seminal plasma alpha-L-fucosidase, Molec. Human Reproduction,8:
221-227.
L.
Riley, M.K. Lange, R.J. Brown,P.J. Cochrane, I-J. Choi, B. Davis,
S. Arcona and J. A. Alhadeff (2000), Analysis
of cathepsin D in human breast cancer: usefulness
of the processed 31 kDa active form of the enzyme as a prognostic
indicator
in node-negative and node-positive patients, Breast Cancer
Researchand
Treatment , 60: 173-179.
B.
Shamideh and J. A. Alhadeff (1999). Characterization
of purified cathepsin D from
malignant human breast tissue, International J. Oncology
, 14: 315-319.
J.
A. Alhadeff (1998), Structure and function of mammalian
alpha-L-fucosidases,Trends in Comparative Biochemistry &
Physiology , 4: 105-118 ( invited review).
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