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Zishen Chen

Respiratory mechanics in obstructed airways: Results of CFD simulations

Department: Mechanical Engineering
Advisor: Jenn Stroud Rossmann

Chronic Obstructive Pulmonary Disorder (COPD) is characterized by long-term breathing problems and poor airflow. [1] Obstructions are usually associated with an inflammatory response in the lung, resulting in increased mucus production. Moreover, over secretion of mucus may have unfavorable impacts on the transport and curative effect of airborne drugs not only because the mucus hinders drugs from accessing targeted tissues but also because the presence of mucus changes the behavior of the flow in airways.

Though the mechanism and physics of aerosolized drug and inhaled particles therapy are well studied, many previous studies have neglected the presence and impact of mucus. As a result, we conducted quantitative and qualitative analysis with commercial CFD software, ANSYS FLUENT, to provide detailed information about respiratory flow characteristics and clues for optimal concentration of inhaled particle (albuterol) or medical gas (NO) mixture treatment.

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