Characterization of cell binding on micro-patterned surface
Departments: IDEAS (Bioengineering) Advisor: Yaling Liu
The goal in tissue engineering is to repair and replace tissues for implantation back into the donor host. Cells are seeded onto a scaffold in order to grow and form a new tissue. The design and biocompatibility of these scaffolds are important to allow proper cell proliferation and alignment. The use of micro-grooved geometries has been shown to promote the adhesion and alignment of cells as they contact and spread across the micro-patterned surface. The aim of this study was to characterize cell binding and adhesion depending on the type of patterned surface, the angle of the patterned surface relative to blood flow, and the groove spacing and height. Bovine Aortic Endothelial cells (BAOECs) were seeded on patterned surfaces via a microfluidic device. Results showed that cell binding density is higher on the groove patterned surface than on the wavy patterned surface. Density of bound cells also increased with increased groove spacing and height.
About Camille Hardy Abeloos:
Camille is a Lehigh University junior graduating in May 2015 with an IDEAS degree, combining bioengineering and biology. She has worked under Professor Liu for about two years, studying cell adhesion on micro-patterned surfaces. After graduation, she plans to go to medical school.